IBD May Negatively Affect Mental Health By Disturbing Gut

IBD May Negatively Affect Mental Health By Disturbing Gut

IBD may negatively affect mental health by disturbing gut. Around 30% of patients with inflammatory bowel disease (IBD) experience depression, anxiety, or both.

A new mice study shows that IBD may disrupt a communication channel between the gut and brain with possible links to mental health. IBD is a group of disorders that cause chronic inflammation in the intestines.

Crohn’s disease and ulcerative colitis are the main types of IBD. Crohn’s disease affects any part of the gastrointestinal tract and ulcerative colitis only affects the large intestine and rectum.

In 2015, IBD diagnosis was received by an estimated 3.1 million adults in the United States or 1.3% of the adult population.

According to recent research, people who experience certain chronic illnesses are likely to increase their risk of developing mental health illnesses. It suggests that IBD directly affects the brain by disrupting the gut-brain axis.

The new study found that a key gateway between the bloodstream and cerebrospinal fluid communication may close to protect the brain from inflammation.

The study now appears in the journal Science.

The researchers in a mouse model of IBD found that closure of the gateway disrupted memory and caused anxiety.

“Our data support the possibility that at least part of the behavioral and cognitive alterations that have been described in patients with IBD may result not from the enhanced inflammation, as generally hypothesized, but rather from the defense strategy activated by the organism to protect the brain from damage and guarantee its function,” the authors conclude.