High cholesterol fuels cancer spread, mice study shows. A recent study investigated the link between high cholesterol levels and cancer cell growth and spread.
The study revealed that high cholesterol levels help cancer spread. According to the discovery, lowering cholesterol levels can be beneficial in the therapeutic procedure for cancer treatment. Cholesterol is a waxy, fat-like substance that's found in all the cells in your body.
Recently, scientists at the Duke University School of Medicine in Durham, NC conducted new research to study cholesterol regulation in cancer cells and mice.
The findings of this study appear in the journal Nature Communications.
The scientists carried out their studies using cell lines and mice models.
They found that that chronic exposure to 27HC led to the growth of tumors that were highly metastatic. This raised the tumor-forming ability and metastatic capacity of the cancer cells.
This new study also goes a step further to explore the processes of action of cholesterol in cancer. Now researchers revealed their plans to extend their research to other types of cancers outside of breast and gynecological cancers.
“The research team observed that cancers that don’t rely on estrogen for growth (estrogen-negative) are still associated with a worse disease by high cholesterol. This strongly suggests that there is at least one other mechanism of cancer action for high cholesterol, which formed the basis for this comprehensive study,” Dr. Lynne Elmore, Ph.D. — senior scientific director of cell biology and preclinical cancer research at the American Cancer Society — said.